Configuration Sharing Optimized Placement and Routing

Reconfigurable systems have been shown to achieve very high computational performance. However, the overhead associated with reconfiguration of hardware remains a critical factor in overall system performance. This paper discusses the development and evaluation of a technique to minimize the delay associated with reconfiguration based upon optimized sharing of configuration bit streams between design contexts. This is achieved through modified placement and routing algorithms

Placement and routing for reconfigurable systems.

Applications using reconfigurable logic have been widely demonstrated to offer better performance over software-based solutions. However, good performance rating is often destroyed by poor reconfiguration latency - time required to reconfigure hardware to perform the new task. Recent research focus on design automation techniques to address reconfiguration latency bottleneck. The contribution to novelty of this thesis is in new placement and routing techniques resulting in minimising reconfiguration latency of reconfigurable systems. This presents a part of design process concerned with positioning and connecting design blocks in a logic gate array. The aim of the research is to optimise the placement and interconnect strategy such that dynamic changes in system functionality can be achieved with minimum delay. A review of previous work in the field is given and the relevant theoretical framework developed. The dynamic reconfiguration problem is analysed for various reconfigurable technologies. Several algorithms are developed and evaluated using a representative set of problem domains to assess their effectiveness. Results obtained with novel placement and routing techniques demonstrate configuration data size reduction leading to significant reconfiguration latency improvements

Specialization integrated strategy of innovations : effective model for emerging regional economy development?

Purpose: The purpose of our work is to propose a strategic model of smart specialization identification around the concept of regional knowledge and cognitive transfer (Double Helix Matrix, DHM). Design/Methodology/Approach: While operationalization of smart specialization-oriented policy is still rather limited because of the lack of agreed development policy tools, we proposed the DHM model developed in order to provide the implementation of regional smart specialization oriented strategy. The model has been statistically verified by multidimensional comparative analysis on the example of a chosen weak innovative emerging region in Poland (Opolskie). Findings: The proposed methodology let us to find the need of redefining the smart specialization concept as a part of regional innovation strategy. Practical Implications: The new approach to the regional innovation policy has been proposed.. The findings have been used to construct the regional policy directives for potential smart specializations development within 2027 perspective. Originality/Value: The new model to conduct regional innovation strategy for smart specialization has been proposed and verified on the example of the weak innovation region.peer-reviewe

Complexity of seemingly simple lipid nanodiscs

Lipid nanodiscs are macromolecular assemblies, where a scaffold protein is wrapped around a nanosized disc of a lipid bilayer, thus protecting the hydrocarbon chains at the disc edges from unfavorable interactions with water. These nanostructures have numerous applications in, e.g., nanotechnology and pharmaceutics, and in investigations of membrane proteins. Here, we present results based on atomistic molecular dynamics simulations combined with electron paramagnetic spectroscopy measurements on the structure and dynamics of lipids in single-component nanodiscs. Our data highlight the existence of three distinctly different lipid fractions: central lipids residing in the center of a nanodisc, boundary lipids in direct contact with a scaffold protein, and intermediate lipids between these two regions. The central lipids are highly ordered and characterized by slow diffusion. In this part of the nanodisc, the membrane is the thickest and characterized by a gel-like or liquid-ordered phase, having features common to cholesterol-rich membranes. The boundary lipids in direct contact with the scaffold protein turned out to be less ordered and characterized by faster diffusion, and they remained in the liquid-disordered phase even at temperatures that were somewhat below the main phase transition temperature (Tm). The enthalpies associated with the central-boundary and central-intermediate transitions were similar to those observed for lipids going through the main phase transition. Overall, the study reveals lipid nanodiscs to be characterized by a complex internal structure, which is expected to influence membrane proteins placed in nanodiscs.Peer reviewe

Analysis of communication in the educational process by means of e-learning

Purpose: The aim of the research is to analyse communication in the educational process by means of e-learning. Approach/Methodology/Design: An analysis of relevant foreign literature was conducted. A communication model and a comparative analysis of synchronous communication tools based on established criteria were indicated. For the comparative analysis normal distribution, descriptive analysis methodology and chi-quadrate distribution with T-student distribution were used. Findings: The analysis of the presented research results shows that most respondents prefer to solve tasks at a distance in any form. Students are satisfied with the adopted solutions, as well as with the offered methods of communication. The introduction of e-learning positively influences the acquisition and dysfunction of knowledge by students. Practical Implications: Distance communication is a very popular means of communication in the 21st century. The use of various tools does not create a barrier and is evidence of high technological progress. Originality/Value: An original literary approach from the most recent international positions was presented and authorial research was carried out on a representative group of respondents. It is shown that the transfer and acquisition of knowledge by means of information and communication technologies has contributed to changes at universities.peer-reviewe

Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis

Within the first week of the disease, acute kidney injury (AKI) is among the most common causes of mortality in acute pancreatitis (AP). Recently, serum angiopoietin-2 (Ang-2) has been associated with hyperdynamic state of the systemic circulation. The aim of this study was to examine the associations between Ang-2 and the clinical AP severity during the first 72 hours of the disease, and organ disfunction, including AKI. Methods. Study included patients admitted to the surgery ward, diagnosed with AP. AKI was diagnosed according to KDIGO guidelines and renal failure according to modified Marshall scoring system. Ang-2 was determined in serum with ELISA. Results. AP was classified as mild (MAP) in 71% of patients, moderately severe (MSAP) in 22%, and severe (SAP) in 8%. During the first 72 hours of AP, 11 patients developed AKI and 6 developed renal failure. Ang-2 at 24, 48, and 72 hours following the onset of AP symptoms significantly predicted SAP and MSAP, as well as AKI and renal failure. Also, Ang-2 significantly correlated with acute phase proteins as well as with the indicators of renal disfunction. Conclusions. Serum Ang-2 may be a relevant predictor of AP severity, in particular of the development of AP-renal syndrome

Fully conjugated [4] chrysaorene. Redox-coupled anion binding in a tetraradicaloid macrocycle

[4]Chrysaorene, a fully conjugated carbocyclic coronoid, is shown to be a low-bandgap π-conjugated system with a distinct open-shell character. The system shows good chemical stability and can be oxidized to well-defined radical cation and dication states. The cavity of [4]chrysaorene acts as an anion receptor toward halide ions with a particular selectivity toward iodides (Ka = 207 ± 6 M–1). The interplay between anion binding and redox chemistry is demonstrated using a 1H NMR analysis in solution. In particular, a well-resolved, paramagnetically shifted spectrum of the [4]chrysaorene radical cation is observed, providing evidence for the inner binding of the iodide. The radical cation–iodide adduct can be generated in thin solid films of [4] chrysaorene by simple exposure to diiodine vapor

Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance

The mechanism of human mitochondrial RNA turnover and surveillance is still a matter of debate. We have obtained a cellular model for studying the role of hSuv3p helicase in human mitochondria. Expression of a dominant-negative mutant of the hSUV3 gene which encodes a protein with no ATPase or helicase activity results in perturbations of mtRNA metabolism and enables to study the processing and degradation intermediates which otherwise are difficult to detect because of their short half-lives. The hSuv3p activity was found to be necessary in the regulation of stability of mature, properly formed mRNAs and for removal of the noncoding processing intermediates transcribed from both H and L-strands, including mirror RNAs which represent antisense RNAs transcribed from the opposite DNA strand. Lack of hSuv3p function also resulted in accumulation of aberrant RNA species, molecules with extended poly(A) tails and degradation intermediates truncated predominantly at their 3′-ends. Moreover, we present data indicating that hSuv3p co-purifies with PNPase; this may suggest participation of both proteins in mtRNA metabolism